Metabolic Journal

Physician-authored guides on GLP-1s, peptides, and metabolic health.

Peptide Stacking: How Physicians Combine Peptides for Maximum Results

Peptide Stacking: How Physicians Combine Peptides for Maximum Results

July 31, 2026 · Metabolic Regen Team

Peptide stacking combines two or more peptides targeting different receptors or biological pathways to achieve synergistic rather than merely additive effects. Physician-designed…

Tesamorelin: The FDA-Approved Growth Hormone Peptide for Body Composition

Tesamorelin: The FDA-Approved Growth Hormone Peptide for Body Composition

July 28, 2026 · Metabolic Regen Team

Tesamorelin is a synthetic GHRH analogue and the only peptide FDA-approved specifically for visceral fat reduction (Egrifta, for HIV-associated lipodystrophy). The LONO…

AOD-9604: The Fat-Loss Peptide Fragment With a Precision Mechanism

AOD-9604: The Fat-Loss Peptide Fragment With a Precision Mechanism

July 24, 2026 · Metabolic Regen Team

AOD-9604 is a synthetic fragment of human growth hormone (amino acids 176-191) engineered to isolate the lipolytic domain while eliminating IGF-1 stimulation…

MOTS-c: The Exercise Mimetic Peptide That Resets Metabolic Health

MOTS-c: The Exercise Mimetic Peptide That Resets Metabolic Health

July 21, 2026 · Metabolic Regen Team

MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA region of mtDNA that activates AMPK, drives glucose uptake independent of insulin,…

SS-31 (Elamipretide): The Mitochondrial Peptide That Restores Cellular Energy

SS-31 (Elamipretide): The Mitochondrial Peptide That Restores Cellular Energy

July 17, 2026 · Metabolic Regen Team

SS-31 is a synthetic tetrapeptide that selectively concentrates in the inner mitochondrial membrane and binds cardiolipin — the structural lipid that determines…

Thymosin Alpha-1 (TA-1): The Immune System Peptide That Resets Your Defense Network

Thymosin Alpha-1 (TA-1): The Immune System Peptide That Resets Your Defense Network

July 14, 2026 · Metabolic Regen Team

Thymosin Alpha-1 is a 28-amino acid peptide that activates dendritic cells, upregulates NK cells, and modulates T-cell responses — producing bidirectional immune…

What Is Peptide Therapy? The Complete Patient Guide

What Is Peptide Therapy? The Complete Patient Guide

July 10, 2026 · Metabolic Regen Team

Peptide therapy uses short-chain amino acid sequences to deliver precise, targeted signals to specific cell receptors — triggering natural processes like growth…

Semax: The Focus Peptide

Semax: The Focus Peptide

July 7, 2026 · Metabolic Regen Team

Semax is a synthetic ACTH(4-10) analogue developed in Russia that increases BDNF by up to 800%, enhances dopamine and serotonin signaling, and…

Selank: Calm Without the Fog

Selank: Calm Without the Fog

July 3, 2026 · Metabolic Regen Team

Selank is a synthetic heptapeptide that modulates GABA, increases BDNF, and reduces cortisol — producing clinical anxiety relief comparable to benzodiazepines without…

When to Upgrade Your GLP-1

When to Upgrade Your GLP-1

July 2, 2026 · Metabolic Regen Team

Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously — producing 24% body weight loss in Phase 2 trials…

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